In recent years, high-precision radiotherapy has become standard radiotherapy. Moreover, stereotactic irradiation of the brain and body (STI), Intensity Modulated Radiotherapy (IMRT) and Volumetric Modulated Arc Radiotherapy (VMAT) are widely used in clinical. Usually, radiation therapy is optimized while with physical and biological dose assessment at the treatment planning, so that based on physical and biologically equivalent dose, we aim to realize an accurate ideal treatment plan with construction of an integrated optimization computing environment using AI (Artificial Intelligence) and deep learning.